CEUS Webinar 2 (EU)
We are pleased to announce an EFSUMB Webinar event, sponsored by Bracco. 'CEUS Webinar 2' with the following speakers of approximately 20 -25 min presentations with a Q&A session to close.
- This EFSUMB Webinar event is sponsored by Bracco.
- Once registered your information will be shared with Bracco so they can keep you informed of future webinar events you may be interested in. If you do not wish for your information to be shared please contact us.
- The Webinar is run by Sintesi InfoMedica.
- Once registered, Sintesi InfoMedica will email you with the link to join the webinar.
- Each Webinar participant is entitled to an EFSUMB certificate of attendance with 1 CME Credit if the participant joins the webinar for the required minimum period. This time period is monitored by Sintesi InfoMedica.
- Each EFSUMB Webinar Event has a maximum of 500 participants to ensure a good quality of presentation is available for all.
- The webinar event is recorded and all presentations will available on the EFSUMB website after the event takes place.
SPEAKER: Dirk André Clevert
Potential of CEUS in renal cancer
SPEAKER: Ernst Michael Jung / Isabel Wiesinger
Potential of CEUS in breast cancer
Worldwide, breast cancer is among the most frequently diagnosed types of cancer (following lung cancer). If detected in an early stage, the chances of curing breast cancer are high and the quality of life remains decent for the patient. Consequently it is important to establish reliable tools for the differentiation between benign and malignant breast lesions as well as for a follow up.
To the present point mammography and conventional B-Mode ultrasound remain the standard diagnostic tools for screening and early detection. And those two modalities are used for the BI-RADS (breast imaging reporting and data system) classification. In the last few years, there is a rising number of research papers, showing that contrast enhanced ultrasound (CEUS) might help to distinguish between malignant and benign nodules [1-5]. CEUS enables a dynamic continuous analysis of micro-vascularization, hence CEUS allows for the differentiation between normal and pathologic tissue since usually angiogenesis in malignant lesions is more prominent than in benign lesions [6, 7].
Clinical applications of CEUS in breast imaging are :
- Evaluation of tumor response after and during neoadjuvant chemotherapy [8,9]
- Differentiation between post-operative scars and recurrence 
- Characterization of benign and malignant breast lesions 
- Evaluation of axillary lymph nodes
Still, CEUS for characterization of breast lesions is not yet fully recommend in the European guidelines  even though CEUS adds excellent value to mammography and sonography . However, CEUS in breast imaging will not replace conventional screening mammography in the next years .
1. Balleyguier C, Opolon P, Mathieu MC, et al. New potential and applications of contrast-enhanced ultrasound of the breast: Own investigations and review of the literature Diagnostic performance of contrast-enhanced ultrasound and enhanced magnetic resonance for breast nodules. European journal of radiology. 2009;69(1):14-23.
2. Zhao H, Xu R, Ouyang Q, et al. Contrast-enhanced ultrasound is helpful in the differentiation of malignant and benign breast lesions Differentiation between benign and malignant breast tumors using kinetic features of real-time harmonic contrast-enhanced ultrasound Breast contrast-enhanced ultrasound: is a scoring system feasible? A preliminary study in China. European journal of radiology. 2010;73(2):288-93.
3. Saracco A, Szabo BK, Aspelin P, et al. Differentiation between benign and malignant breast tumors using kinetic features of real-time harmonic contrast-enhanced ultrasound Breast contrast-enhanced ultrasound: is a scoring system feasible? A preliminary study in China. Acta radiologica (Stockholm, Sweden : 1987). 2012;53(4):382-8.
4. Xiao X, Ou B, Yang H, Wu H, Luo B. Breast contrast-enhanced ultrasound: is a scoring system feasible? A preliminary study in China. PloS one. 2014;9(8):e105517.
5. Luo J, Chen JD, Chen Q, et al. Predictive model for contrast-enhanced ultrasound of the breast: Is it feasible in malignant risk assessment of breast imaging reporting and data system 4 lesions? World J Radiol. 2016;8(6):600-9.
6. Engels K, Fox SB, Whitehouse RM, et al. Distinct angiogenic patterns are associated with high-grade in situ ductal carcinomas of the breast Color Doppler flow criteria of breast lesions. J Pathol. 1997;181(2):207-12.
7. Madjar H, Prompeler HJ, Sauerbrei W, Wolfarth R, Pfleiderer A. Color Doppler flow criteria of breast lesions. Ultrasound in medicine & biology. 1994;20(9):849-58.
8. Corcioni B, Santilli L, Quercia S, et al. Contrast-enhanced US and MRI for assessing the response of breast cancer to neoadjuvant chemotherapy(). J Ultrasound. 2008;11(4):143-50.
9. Szabo BK, Saracco A, Tanczos E, et al. Correlation of contrast-enhanced ultrasound kinetics with prognostic factors in invasive breast cancer Contrast-enhanced US and MRI for assessing the response of breast cancer to neoadjuvant chemotherapy(). European radiology. 2013;23(12):3228-36.
10. Stuhrmann M, Schwarz T, Schietzel M. [Breast cancer recurrence versus scar. Ultrasonographic differentiation using Levovist as the contrast medium]. Ultraschall in der Medizin (Stuttgart, Germany : 1980). 2001;22(1):2-6.
11. Du YR, Wu Y, Chen M, et al. Application of contrast-enhanced ultrasound in the diagnosis of small breast lesions The added value of contrast-enhanced ultrasound to conventional ultrasound in differentiating benign and malignant solid breast lesions: a systematic review and meta-analysis Contrast-Enhanced Ultrasound Imaging of Breast Masses: Adjunct Tool to Decrease the Number of False-Positive Biopsy Results Impact of parametric imaging on contrast-enhanced ultrasound of breast cancer. Clinical hemorheology and microcirculation. 2018;70(3):291-300.
12. Piscaglia F, Nolsoe C, Dietrich CF, et al. The EFSUMB Guidelines and Recommendations on the Clinical Practice of Contrast Enhanced Ultrasound (CEUS): update 2011 on non-hepatic applications. Ultraschall in der Medizin (Stuttgart, Germany : 1980). 2012;33(1):33-59.
13. Jung EM, Jungius KP, Lenhart M, Dengler M, Becker H, Rupp N. [Tissue harmonic imaging (THI) and contrast harmonic imaging (CHI) for sonographically guided vacuum-assisted biopsy of mammographically occult breast tumors]. RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin. 2004;176(10):1416-22.
SPEAKER: Mirko D'Onofrio
Potential of CEUS in pancreatic cancer
1. To learn about actual indications and applications of contrast-enhanced US (CEUS)
2. To show better parameter settings for optimal technical results
3. To compare CEUS to CT and MRI